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Go back. Cellular functions are mediated through complex systems of macromolecules and metabolites linked through biochemical and physical interactions, represented in interactome models as 'nodes' and 'edges', respectively. Recurrence of mutations suggested that these 'hotspot' sites were positively selected. Published by Oxford University Press. Chromatin regulatory genes were more frequently mutated in urothelial carcinoma than in any other common cancer studied so far, indicating the future possibility of targeted therapy for chromatin abnormalities. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. C5 deposition, after incubation with normal human serum, was higher in lung cancer cell lines than in nonmalignant bronchial epithelial cells. References Modulation of the anti-tumor immune response by complement. We conclude that the breadth and quality of immunotherapeutic approaches and the types of cancers that can be treated will increase significantly in the foreseeable future. Xiujuan Wang Xiaomu Wei. Physical exercise and lack of obesity in adolescence were associated with significantly delayed breast cancer onset. The DESeq2 package is available at http: A cam.